Pemanfaatan dan Bioaktivitas Jatropha gossypiifolia L.

Marina Silalahi

doi:10.33541/jpvol6Iss2pp102

Marina Silalahi Prodi Pendidikan Biologi, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Kristen Indonesia

DOI: https://doi.org/10.33541/jpvol6Iss2pp102

Abstract

Jatropha gossypiifolia (Euphorbiaceae) is a plant introduced in Indonesia, and its use as traditional medicine has not been widely used. This study aims to explain the botany, utilization, bioactivity and toxicity of J. gossypiifolia. The research method was carried out using library research, especially articles that can be accessed online using the keywords J. gossypiifolia, uses J. gossypiifolia and bioactivity of J. gossypiifolia. Morphologically, J. gossypiifolia is easily recognized from its young red leaves which produce white latex and red flowers. The J. gossypiifolia is a medicinal plant that is widely used in various countries, especially throughout Africa and America. In traditional traditional medicine such as overcoming vomiting), promoting blood flow, overcoming itching, blood purifier, antibacterial, anti-fertile, anticancer, antiulcer, and stomach ache. The bioactivity as an anti-microbial, anti-oxidant, anti-inflammatory anti-fertility and hepatoprotective analgesic, of J. gossypiifolia is anticoagulant, anti-hypertensive, anti-Alzheimer’s, and anti-diabetes mellitus. The extract of J. gossypiifolia is capable of growing Plasmodium berghei which causes malarial fever, which has better activity than quinine. Therefore, it is very potential to be developed as an alternative in the treatment of malaria, therefore it needs to be studied further. The latex produced from the stems and leaves of J. gossypiifolia is toxic and therefore needs to be used with caution.

Keywords: J. gossypiifolia, anti-malarial, anti-microbial

References

Aboaba, S.A., Adebayo, M.A., Ogunwande, I.A., & Olayiwola, T.O. (2015). Volatile constituents of Jatropha gossypifolia L. grown in Nigeria. American Journal of Essential oils and Natural products, 2(4), 08-11.

Abreu, I.C., Marinho, A. S., Paes, A.M., Freire, S. M., Olea, R.S., Borges, M.O., & Borges, A. C. (2003). Hypotensive and vasorelaxant effects of ethanolic extract from Jatropha gossypiifolia L. in rats. Fitoterapia, 74(7-8), 650-657.

Akshada, K., Madhuri, P., Kiran, W., Sandip, P., Magdum, C.S., & Naikwade, N.S. (2008). A comprehensive review of Jatropha gossypifolia Linn. Pharmacognosy Reviews, 2(4 suppl.), 2-6.

Almeida, P.M., Araújo, S.S., Santos, I.R.M.R., Marin-Morales, M.A., Benko-Iseppon, A.M., Santos, A.V., Randau, K.P., & Brasileiro-Vidal, A.C. (2016). Genotoxic potential of leaf extracts of Jatropha gossypiifolia L. Genetics and Molecular Research, 15(1), 1-8.

Apu, A.S., Hossain, F., Rizwan, F., Bhuyan, S.H., Matin, M., & Jamaluddin, A. T. M. (2012). Study of pharmacological activities of methanol extract of Jatropha gossypifolia fruits. Journal of basic and clinical pharmacy, 4(1), 20.

Bahadur, B., Murthy, G.V.S., & Sujatha, M. (2013). Pollen of Jatropha L. taxonomic and phylogenetic considerations. Jatropha, Challenges for a New Energy Crop: Volume 2: Genetic Improvement and Biotechnology, 45-74.

Bharathy, V., Sumathy, B. M., & Uthayakumari, F. (2012). Determination of phytocomponents by GC-MS in leaves of Jatropha gossypifolia L. Science Research Reporter, 2(3), 286-290.

Dhale, D. A., & Birari, A. R. (2010). Preliminary screening of antimicrobial and phytochemical studies of Jatropha gossypifolia Linn. Recent Research In Science and Technology, 2(7).

Divakara, B.N., Upadhyaya, H.D., Wani, S.P., & Gowda, C. L. (2010). Biology and genetic improvement of Jatropha curcas L.: a review. Applied Energy, 87(3), 732-742.

Félix-Silva, J., Souza, T., Camara, R.B.B.G., Cabral, B., Silva-Júnior, A.A., Rebecchi, I.M.M., Zucolotto,S.M., Rocha, H.A.O., & Fernandes-Pedrosa, M.D.F. (2014). In vitro anticoagulant and antioxidant activities of Jatropha gossypiifolia L. (Euphorbiaceae) leaves aiming therapeutical applications. BMC Complementary and Alternative Medicine, 14(1), 1-13.

Félix-Silva, J., Giordani, R.B., Silva-Jr, A.A.D., Zucolotto, S.M., & Fernandes-Pedrosa, M.D.F. (2014b). Jatropha gossypiifolia L.(Euphorbiaceae): a review of traditional uses, phytochemistry, pharmacology, and toxicology of this medicinal plant. Evidence-Based Complementary and Alternative Medicine, 2014.

Félix-Silva, J., Souza, T., Menezes, Y.A., Cabral, B., Câmara, R.B., Silva-Junior, A. A., Hugo A.O. Rocha, Ivanise M.M. Rebecchi, Silvana M. Zucolotto & Fernandes-Pedrosa, M.F. (2014C). Aqueous leaf extract of Jatropha gossypiifolia L. (Euphorbiaceae) inhibits enzymatic and biological actions of Bothrops jararaca snake venom. PLoS One, 9(8), e104952.

Félix-Silva, J., Gomes, J.A.S., Barbosa, L.M.Q., Pinheiro, I.T.M.G., Soares, L.A. L., Silva-Júnior, A. A., & Fernandes-Pedrosa, M.F. (2014D). Systemic and local anti-inflammatory activity of aqueous leaf extract from Jatropha gossypiifolia L. (Euphorbiaceae). Int J Pharm Pharm Sci, 6(6), 142-5.

Granados, S., Balcázar, N., Guillén, A., & Echeverri, F. (2015). Evaluation of the hypoglycemic effects of flavonoids and extracts from Jatropha gossypifolia L. Molecules, 20(4), 6181-6193.

Hidayat, I.R.S., & Napitupulu, R.M., (2015). Kitab Tumbuhan Obat. Agriflo.

https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:323930-2#other-data (diakses 20 Maret 2023 pukul 13.05).

Jain, S., Choudhary, G.P., & Jain, D.K. (2012). Pharmacological evaluation of anti–fertility activity of ethanolic extract of Jatropha gossypifolia leaf in female albino mice. Asian Pacific Journal of Tropical Biomedicine, 2(3), S1671-S1674.

Kharat, A.R., Dolui, A.K., & Das, S. (2011). Free radical scavenging potential of Jatropha gossypifolia. Asian Journal of Chemistry, 23(2), 799-801.

Kumar, A., & Singh, N. (2012). Jatropha gossypiifolia L.: a potential genetic resource for herbal dye. Genetic Resources and Crop Evolution, 59, 949-954.

Mariz, S.R., Cerqueira, G.S., Araújo, W.C., Dantas, J.G., Ramalho, J.A., Palomaro, T.V., & Medeiros, I.A.D. (2012). Chronic toxicologic study of the ethanolic extract of the aerial parts of Jatropha gossypiifolia in rats. Revista Brasileira de Farmacognosia, 22, 663-668.

Oduola, T., Popoola, G.B., Avwioro, O.G., Oduola, T.A., Ademosun, A.A., & Lawal, M.O. (2007). Use of Jatropha gossypifolia stem latex as a haemostatic agent: how safe is it. Journal of Medicinal Plants Research, 1(1), 014-017.

Oduola, T., Adeosun, G.O., Oduola, T.A., & Ovie, G. (2005). Mechanism of action of Jatropha gossypifolia stem latex as a haemostatic agent. European Journal of General Medicine, 2(4), 140-143.

Oduola, T., Avwioro, O.G., & Ayanniyi, T.B. (2005b). Suitability of the leaf extract of Jatropha gossypifolia as an anticoagulant for biochemical and haematological analyses. African Journal of Biotechnology, 4(7), 679-681.

Ogundare, A.O. (2007). Antimicrobial effect of Tithonia diversifolia and Jatropha gossypifolia leaf extracts. Trends in applied sciences Research, 2(2), 145-150.

Onyegbule, F.A., Bruce, S.O., Onyekwe, O.N., Onyealisi, O.L., & Okoye, P.C. (2019). Evaluation of the in vivo antiplasmodial activity of ethanol leaf extract and fractions of Jatropha gossypifolia in Plasmodium berghei infected mice. Journal of Medicinal Plants Research, 13(11), 269-279.

Okoh, S.O., Iweriebor, B. C., Okoh, O.O., Nwodo, U.U., & Okoh, A.I. (2016). Antibacterial and antioxidant properties of the leaves and stem essential oils of Jatropha gossypifolia L. BioMed research international, 2016.

Panda, B.B., Gaur, K., Kori, M.L., Tyagi, L.K., Nema, R.K., Sharma, C.S., & Jain, A.K. (2009). Anti-inflammatory and analgesic activity of Jatropha gossypifolia in experimental animal models. Global Journal of Pharmacology, 3(1), 1-5.

Panda, B.B., Gaur, K., Nema, R.K., Sharma, C.S., Jain, A.K., & Jain, C.P. (2009b). Hepatoprotective activity of Jatropha gossypifolia against carbon tetrachloride-induced hepatic injury in rats. Asian Journal of Pharmaceutical and Clinical Research, 2(1), 50-54.

Pangestu, N. S., Nurhamidah, N., & Elvinawati, E. (2017). Aktivitas antioksidan dan antibakteri ekstrak daun Jatropha gossypifolia L. Alotrop, 1(1).

Rofida, S. (2015). Antioxidant activity of Jatropha curcas and Jatropha gossypifolia by DPPH method. Pharmacy: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia), 2(6), 281-284.

Ruchi, S., & Renu, S. (2010). Analysis of the phytochemical content and anti-microbial activity of Jatropha gossypifolia L. Archives of applied science Research, 2(5), 285-291.

Saleem, H., Ahmad, I., Ashraf, M., Gill, M.S.A., Nadeem, M.F., Shahid, M.N., & Barkat, K. (2016). In vitro studies on anti-diabetic and anti-ulcer potentials of Jatropha gossypifolia (Euphorbiaceae). Tropical journal of pharmaceutical research, 15(1), 121-125.

Saleem, H., Ahmad, I., Shahid, M. N., Gill, M.S.A., Nadeem, M.F., Mahmood, W., & Rashid, I. (2016b). In vitro acetylcholinesterase and butyrylcholinesterase inhibitory potentials of Jatropha gossypifolia plant extracts. Acta Pol. Pharm, 73(2), 419-423.

Vijayakumar, A.R., Daniel, E.P., Ilavarasan, R., Venkataraman, S., & Vijayakumar, S. (2016). Ulcer protective activity of Jatropha gossypiifolia Linn. in wistar rats. Pharmacognosy research, 8(Suppl 1), S61.

Wu, Q., Patocka, J., Nepovimova, E., & Kuca, K. (2019). Jatropha gossypiifolia L. and its biologically active metabolites: A mini review. Journal of Ethnopharmacology, 234, 197-203.

Xavier-Santos, J. B., Félix-Silva, J., Passos, J. G., Gomes, J. A., Fernandes, J.M., Garcia, V.B., de Araujo-Junior, R.F., Zucolotto, S.M., Silva-Junior, A.A. & Fernandes-Pedrosa, M.F. (2018). Development of an effective and safe topical anti-inflammatory gel containing Jatropha gossypiifolia leaf extract: results from a pre-clinical trial in mice. Journal of Ethnopharmacology, 227, 268-278.