Pemanfaatan, Toksisitas dan Glikosida Jantung dari Digitalis purpurea L
Abstract
Digitalis purpurea (Schrophulariaceae) is used by the local Indonesian community as an ornamental plant, even though this plant has high toxicity and has the potential to treat heart problems. This study aims to explain the botany, bioactivity and toxicity of D. purpurea based on literature studies. Literature was obtained online, especially Google scholar using the keywords Digitalis purpurea, bioactivity D. purpurea, and glycoside heart. In Europe, D. purpurea is very popular to treat congestive heart failure and has been used since 200 years ago, but it is very toxic to humans. Digitalis poisoning causes anorexia, nausea, vomiting, and diarrhea, yellow or jaundice vision, appearance of blurred lines, decreased heart rate, and weight loss. D. purpurea's bioactivity includes overcoming heart failure, antioxidants, anti-cancer/tumor. Cardiac glycosides present in D. purpurea include cardenolides, digitoxin, gitoxin, purpureaside A, purpureaside B, acteoside and purpureaside C, which are related to their bioactivity. The toxicity and inotropic effects of cardiac glycosides result directly from inhibition of membrane-bound Na+K+_ATPase, an enzyme involved in the transport of Na+K+ across cell membranes. The use of D. purpurea needs strict control so that side effects can be minimized.
References
Agrawal, A. A., Petschenka, G., Bingham, R. A., Weber, M. G., & Rasmann, S. (2012). Toxic cardenolides: chemical ecology and coevolution of specialized plant–herbivore interactions. New Phytologist, 194(1), 28-45.
Bräuchler, C., Meimberg, H., & Heubl, G. (2004). Molecular phylogeny of the genera Digitalis L. and Isoplexis (Lindley) Loudon (Veronicaceae) based on ITS-and trnL-F sequences. Plant Systematics and Evolution, 248(1), 111-128.
Deluca, M.E., Seldes, A.M., & Gros, E.G. (1989). Biosynthesis of digitoxin in Digitalis purpurea. Phytochemistry, 28(1), 109-111.
Evans, F.J., & Cowley, P.S. (1972). Cardenolides and spirostanols in Digitalis purpurea at various stages of development. Phytochemistry, 11(10), 2971-2975.
Fujii, Y., Ikeda, Y., & Yamazaki, M. (1989). High-performance liquid chromatographic determination of secondary cardiac glycosides in Digitalis purpurea leaves. Journal of Chromatography, 479, 319-325.
Fujii, Y., Ikeda, Y., & Yamazaki, M. (1990). Quantitative determination of digitalis glycosides in Digitalis purpurea leaves by reversed-phase thin-layer chromatography. Journal of liquid chromatography, 13(10), 1909-1919.
Fujino, T., Kuroda, M., Matsuo, Y., Kubo, S., Tamura, C., Sakamoto, N., Yoshihiro Mimaki & Hayakawa, M. (2015). Cardenolide glycosides from the seeds of Digitalis purpurea exhibit carcinoma-specific cytotoxicity toward renal adenocarcinoma and hepatocellular carcinoma cells. Bioscience, Biotechnology, and Biochemistry, 79(2), 177-184.
Gavidia, I., Tarrío, R., Rodríguez-Trelles, F., Pérez-Bermúdez, P., & Seitz, H.U. (2007). Plant progesterone 5β-reductase is not homologous to the animal enzyme. Molecular evolutionary characterization of P5βR from Digitalis purpurea. Phytochemistry, 68(6), 853-864.
Jin, Q., Jin, H.G., Shin, J.E., Hong, J.K., & Woo, E.R. (2011). Phenylethanoid Glycosides from Digitalis purpurea L. Bulletin of the Korean Chemical Society, 32(5), 1721-1724.
Kuroda, M., Kubo, S., Matsuo, Y., Atou, T., Satoh, J., Fujino, T., M hayakawa & Mimaki, Y. (2013). New cardenolide glycosides from the seeds of Digitalis purpurea and their cytotoxic activity. Bioscience, biotechnology, and biochemistry, 77(6), 1186-1192.
Kuate S.P., Padua R.M., Eisenbeiss W.F., Kreis W. (2008) Purification and characterization of malonyl-coenzyme A: 21-hydroxypregnane 21-Omalonyltransferase (Dp21MaT) from leaves of Digitalis purpurea L. Phytochemistry 69, 619-626.
Kreis, W., Hensel, A., & Stuhlemmer, U. (1998). Cardenolide Biosynthesis in Foxglove1. Planta medica, 64(06), 491-499.
Lee, J.Y., Woo, E., & Kang, K.W. (2006). Screening of new chemopreventive compounds from Digitalis purpurea. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 61(4), 356-358.
Lopez-Lazaro M., Palma De La Pena N, Pastor N., Martin-Cordero C., Navarro E., Cortes F., Ayuso M.J., Toro M.V.: Anti-tumor activity of Digitalis purpurea L. subsp. heywoodii. Planta Med 2003, 69:701-704.
Matsumoto, M., Koga, S., Shoyama, Y., & Nishioka, I. (1987). Phenolic glycoside composition of leaves and callus cultures of Digitalis purpurea. Phytochemistry, 26(12), 3225-3227.
Maier, M.S., Seldes, A.M., & Gros, E.G. (1986). Biosynthesis of the butenolide ring of cardenolides in Digitalis purpurea. Phytochemistry, 25(6), 1327-1329.
Medarde, M., Caballero, E., Tomé, F., & San Feliciano, A. (2001). Cardenolides and diterpenes as a source of and model for positive ionotropic agents. Pharmaceutical biology, 39(sup1), 53-62.
Navarro, E., Alonso, P.J., Alonso, S.J., Trujillo, J., Pérez, C., Toro, M.V., & Ayuso, M.J. (2000). Cardiovascular activity of a methanolic extract of Digitalis purpurea spp. heywoodii. Journal of Ethnopharmacology, 71(3), 437-442.
Nengroo, Z.R., & Rauf, A. (2020). Inula racemosa and Digitalis purpurea from Kashmir: fatty acid composition, antioxidant, antibacterial activities, and functional group evaluation. Flavour and fragrance journal 35(6), 653-665
Oh, J.W., Lee, J.Y., Han, S. H., Moon, Y.H., Kim, Y.G., Woo, E.R., & Kang, K.W. (2005). Effects of phenylethanoid glycosides from Digitalis purpurea L. on the expression of inducible nitric oxide synthase. Journal of pharmacy and pharmacology, 57(7), 903-910.
Pérez-Alonso, N., Wilken, D., Gerth, A., Jähn, A., Nitzsche, H.M., Kerns, G., & Jiménez, E. (2009). Cardiotonic glycosides from biomass of Digitalis purpurea L. cultured in temporary immersion systems. Plant Cell, Tissue and Organ Culture (PCTOC), 99(2), 151-156.
Pérez‐Bermúdez, P., Moya Garcia, A.A., Tuñón, I., & Gavidia, I. (2010). Digitalis purpurea P5βR2, encoding steroid 5β‐reductase, is a novel defense‐related gene involved in cardenolide biosynthesis. New Phytologist, 185(3), 687-700.
Roca-Pe´rez L., Boluda R., Gavidia I., Pe´rez-Bermu´dez P. (2004) Seasonal cardenolide production and Dop5br gene expression in natural populations of Digitalis obscura. Phytochemistry 65,1869–1878
Schwinger R.H.G., Bundgaard H., Muller-Ehmsen J., Kjeldsen K. (2003) The Na, K-ATPase in the failing human heart. Cardiovasc Res 57:913–920.
Sharma, A., & Purkait, B. (2012). Identification of medicinally active ingredient in ultra-diluted Digitalis purpurea: Fluorescence spectroscopic and cyclic-volta-metric study. Journal of Analytical Methods in Chemistry.
Suwanditya, R.K., Sumiwi, S.A., & Wardhana, Y.W. (2019). Peran senyawa flavonoid dan glikosida jantung dalam aktivitas kardiotonik. Farmaka, 17(1), 58-65.
Usai, M., Atzei, A.D., & Marchetti, M. (2007). Cardenolides content in wild Sardinian Digitalis purpurea L. populations. Natural Product Research, 21(9), 798-804.
Usai, M., Atzei, A.D., & Marchetti, M. (2007b). Cardenolides content in wild Sardinian Digitalis purpurea L. populations. Natural Product Research, 21(9), 798-804.
Wiesner, K., & Tsai, T.Y.R. (1986). Some recent progress in the synthetic and medicinal chemistry of cardioactive steroid glycosides. Pure and Applied Chemistry, 58(5), 799-810.
Wu, B., Li, Y., Yan, H., Ma, Y., Luo, H., Yuan, L., S Chen & Lu, S. (2012). Comprehensive transcriptome analysis reveals novel genes involved in cardiac glycoside biosynthesis and mlncRNAs associated with secondary metabolism and stress response in Digitalis purpurea. BMC genomics, 13(1), 1-22.
Yang, B., Liu, H., Yang, J., Gupta, V.K., & Jiang, Y. (2018). New insights on bioactivities and biosynthesis of flavonoid glycosides. Trends In Food Science & Technology, 79, 116-124.
Zahid, H., & Rizwani, G.H. (2016). Digitalis purpurea L.: A concise drug review with probable clinical uses. Hamdard Medicus, 59(2), 25-32.
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